The Gene

An Intimate History

By Siddhartha Mukherjee

Narrated by Dennis Boutsikaris
19 hours 22 minutes

From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human when we learn to “read” and “write” our own genetic information?

The extraordinary Siddhartha Mukherjee has a written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Throughout the narrative, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—cuts like a bright, red line, reminding us of the many questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In superb prose and with an instinct for the dramatic scene, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Thomas Morgan to Crick, Watson and Rosa Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome.

As The New Yorker said of The Emperor of All Maladies, “It’s hard to think of many books for a general audience that have rendered any area of modern science and technology with such intelligence, accessibility, and compassion…An extraordinary achievement.” Riveting, revelatory, and magisterial history of a scientific idea coming to life, and an essential preparation for the moral complexity introduced by our ability to create or “write” the human genome, The Gene is a must-read for everyone concerned about the definition and future of humanity. This is the most crucial science of our time, intimately explained by a master.

The Gene is a magnificent synthesis of the science of life, and forces all to confront the essence of that science as well as the ethical and philosophical challenges to our conception of what constitutes being human.

Paul Berg, Winner of the Nobel Prize in Chemistry

This is perhaps the greatest detective story ever told—a millennia-long search, led by a thousand explorers, from Aristotle to Mendel to Francis Collins, for the question marks at the center of every living cell. Like The Emperor of All Maladies, The Gene is prodigious, sweeping, and ultimately transcendent. If you’re interested in what it means to be human, today and in the tomorrows to come, you must read this book.

Anthony Doerr, Author of All the Light We Cannot See

About the Author

Siddhartha Mukherjee is the author of The Emperor of All Maladies: A Biography of Cancer, winner of the 2011 Pulitzer Prize in general nonfiction, and The Laws of Medicine. He was the editor of Best Science Writing in 2013. Mukherjee is an assistant professor of medicine at Columbia University and a cancer physician and researcher. A Rhodes scholar, he graduated from Stanford University, University of Oxford, and Harvard Medical School. He has published articles in Nature, The New England Journal of Medicine, The New York Times, and Cell.

He lives in New York with his wife and daughters.

Reviews

The story of this invention and this discovery has been told, piecemeal, in different ways, but never before with the scope and grandeur that Siddhartha Mukherjee brings to his new history, “The Gene.” He fully justifies the claim that it is “one of the most powerful and dangerous ideas in the history of science. As he did in his Pulitzer ­Prize-winning history of cancer, “The Emperor of All Maladies” (2010), Mukherjee views his subject panoptically, from a great and clarifying height, yet also intimately.

James Gleick, The New York Times

Mukherjee is right to nudge us away from any simplistic notion that our genes determine our physical and mental identity. The scientific jury is still out on the various versions of epigenesis, but Mukherjee has done much good by concluding his history of genetics with provocations to think critically about some ways we commonly oppose heredity and the environment. Sound bites rarely represent sound science. Genes are not us. It would be as foolish to deny what our genes do as it would be to assert the sufficiency of our genes in making us who we are.

Steven Shapin, The Guardian

Author

Narrator
Dennis Boutsikaris

ISBN
9781508211396

Length
19 hours 22 minutes

Language
English

Publisher
Simon & Schuster Audio

Publication Date

Abridged
No

  • It is one thing to try to understand how genes influence human identity or sexuality or temperament. It is quite another thing to imagine altering identity or sexuality or behavior by altering genes.
  • The crucial driver of evolution, Darwin understood, was not nature’s sense of purpose, but her sense of humor.
  • Cancer, perhaps, is an ultimate perversion of genetics—a genome that becomes pathologically obsessed with replicating itself.

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